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non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer

stearic acid-acylated methoxypoly(ethylene glycol)5000-graft-N-ε-poly-L-lysine hydrophobic core protected graft copolymer MPEG5-PLL21-stearoyl HC-PGC
Type Biomolecule
Formula
Role raw materials
2

1-(2-(2-(3,5-dimethylbenzoyl)-4-methylphenoxy)ethyl)pyrimidine-2,4(1H,3H)-dione

benzophenone-uracyl scaffold-derived Z007 BPU Z007 Z007
Type Single Compound
Formula C22H22N2O4
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
recombinant heterodimeric (p66/p51) wild type HIV-1 reverse transcriptase (HIV RT)

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1-(2-(2-(3,5-dimethylbenzoyl)-4-methylphenoxy)ethyl)pyrimidine-2,4(1H,3H)-dione
  • stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  1. gleMUjjIqs3yrlytcjJnJTaB
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Number-corrected hydrodynamic diameter: 128 - 322 nm

Z-average hydrodynamic diameter: 129.0 nm

Medium: HEPES buffered saline

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1-(2-(2-(3,5-dimethylbenzoyl)-4-methylphenoxy)ethyl)pyrimidine-2,4(1H,3H)-dione
  • stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  1. zKAfkvXIxh0Ogy2qYoSuADHs
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Number-corrected hydrodynamic diameter: 81 - 129 nm

Z-average hydrodynamic diameter: 151.6 nm

Medium: HEPES buffered saline

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1-(2-(2-(3,5-dimethylbenzoyl)-4-methylphenoxy)ethyl)pyrimidine-2,4(1H,3H)-dione
  • stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  1. ouY0kAmGLLibpYWtA25upPsj
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • oleic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  • 1-(2-(2-(3,5-dimethylbenzoyl)-4-methylphenoxy)ethyl)pyrimidine-2,4(1H,3H)-dione
  1. DWkj4PKfhpyEI5bMGitpNafn
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Size: not specified

Medium/Support: none

References

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