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GDDC-M/anti-Luc siRNA complexes

Based on

11 Articles
2017 Most recent source

Composition

1

PCB-P(DPAx-co-DMAEMAy)-PG nanomicelles

GDDC8 nanomicelles GDDC8-M GDDC-M
Type Nano Material
Formula
Role carriers
2

small interfering ribonucleic acid

small interfering RNA siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
genetic engineering

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medicine/veterinary

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
athymic male BALB/c nude mouse bearing human colonic carcinoma HCT-8/T tumor xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. zFE
Product

GDDC-M/anti-Luc siRNA complexes

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. AVH
Product

GDDC-M/anti-Luc siRNA complexes

Hydrodynamic diameter: 83.4 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. fT9
Product

GDDC-M/anti-Luc siRNA complexes

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. TH4
Product

GDDC-M/anti-Luc siRNA complexes

Size: not specified

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • S,S-2-[3-[5-amino-1- carboxypentyl]ureido]pentanedioic acid-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate)
  • methoxy-polyethylene glycol-block-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-oligoarginine)
  • small interfering RNA
  1. eJP
Product

GDDC-M/anti-Luc siRNA complexes

Size: not specified

Medium/Support: none

References

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