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lopinavir/ritonavir-loaded polymer nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(vinyl alcohol)

polyvinyl alcohol PVOH PVAI PVA
Type Polymer
Formula
Role core
2

d-α-tocopheryl polyethylene glycol succinate

TPGS
Type Polymer
Formula
Role layer
3

[1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide

lopinavir LPV
Type Single Compound
Formula C37H48N4O5
Role loaded material
4

(5S,8S,10S,11S)-10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid 5-thiazolyl-methyl ester

ritonavir RTV
Type Single Compound
Formula C37H48N6O5S2
Role loaded material

Properties

Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
X-ray diffraction

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Biological effects

Biological system Test details Source
male Sprague-Dawly rat

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(vinyl alcohol)
  • [1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide
  • d-α-tocopheryl polyethylene glycol succinate
See all (4)
  1. VeAjyGgAqeJVA0z
  2. F9VpG
Product

lopinavir/ritonavir-loaded polymer nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(vinyl alcohol)
  • [1S-[1R*,(R*),3R*,4R*]]-N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenyl-methyl)pentyl]tetrahydro-a-(1-methyl-ethyl)-2-oxo-1-(2H)-pyrimidineacetamide
  • (5S,8S,10S,11S)-10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid 5-thiazolyl-methyl ester
See all (4)
  1. ErndW8WTR0
  2. GOSMd
Product

lopinavir/ritonavir-loaded polymer nanoparticles

References

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