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docetaxel/diclofenac-loaded spherical polymeric nanoconstructs

Based on

1 Articles
2016 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

lipid mixture

Type Complex Compound
Formula
Role layer
3

diclofenac

DS
Type Single Compound
Formula C14H11Cl2NO2
Role loaded material
4

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
U87-MG glioblastoma bearing female CD-1 nude mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • diclofenac
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  1. stu1IGuS2a
Product

docetaxel/diclofenac-loaded spherical polymeric nanoconstructs

Hydrodynamic diameter: 157.00 - 174.20 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • diclofenac
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  1. IZmuQyxxhX
Product

docetaxel/diclofenac-loaded spherical polymeric nanoconstructs

Hydrodynamic diameter: 152.10 - 158.50 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • diclofenac
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  1. 11iCQ4PS1z
Product

docetaxel/diclofenac-loaded spherical polymeric nanoconstructs

Hydrodynamic diameter: 154.50 - 156.84 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • diclofenac
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  1. 7BB3BxypS8
Product

docetaxel/diclofenac-loaded spherical polymeric nanoconstructs

Size: not specified

Medium/Support: none

References

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