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technetium-99 m labeled and Annexin V- modified gold nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

PEG-NH2-covered gold nanoparticles

PEG-NH2-covered AuNP GNP-PEG-NH2
Type Nano Material
Formula
Role core
2

4-(N-maleimidomethyl)cyclohexane-1-carboxylate moiety

sulfo-SMCC moiety
Type Single Compound
Formula -C12H14NO4
Role layer
3

mercaptoacetic acid

thioglycolic acid TGA
Type Single Compound
Formula C2H4O2S
Role layer
4

Annexin V

Type Biomolecule
Formula
Role layer
5

S-acetylmercaptoacetyltriglycinate moiety

MAG3 moiety
Type Single Compound
Formula -C10H14N3O5S
Role layer
6

technetium

Type Single Compound
Formula 99Tc
Role loaded material

Properties

General physical and chemical properties

Property Value Source
stability

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Applications

Area Application Source
diagnostics

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Characterization

Method Source
UV-Vis-NIR optical spectroscopy

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Biological effects

Biological system Test details Source
apoptotic mouse macrophage RAW 264.7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
Product

technetium-99 m labeled and Annexin V- modified gold nanoparticles

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycinate
  • PEG-NH2-covered gold nanoparticles
  • 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt
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Product

technetium-99 m labeled and Annexin V- modified gold nanoparticles

Method 3

Type: Physical formation
Source:
Product

technetium-99 m labeled and Annexin V- modified gold nanoparticles

References

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