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Paclitaxel-cholesterol conjugate-loaded DSPE-PEG:PC nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

water

Type Single Compound
Formula H2O
Role core
2

lipid mixture

Type Complex Compound
Formula
Role layer
3

C81H105N3O18

Type Single Compound
Formula C81H105N3O18
Role fillers

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
breast cancer 4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • C81H105N3O18
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino-(polyethylene glycol)
  1. 3iQQXxHnjy93tAx
Product

Paclitaxel-cholesterol conjugate-loaded DSPE-PEG:PC nanoparticles

Hydrodynamic diameter: 170 - 190 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • C81H105N3O18
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino-(polyethylene glycol)
  1. 0rMpMSvgOFi1AhM
Product

Paclitaxel-cholesterol conjugate-loaded DSPE-PEG:PC nanoparticles

Size: ~ 100 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • C81H105N3O18
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino-(polyethylene glycol)
  1. ZswDx6eYU07z6y9
Product

Paclitaxel-cholesterol conjugate-loaded DSPE-PEG:PC nanoparticles

Hydrodynamic diameter: 160 - 180 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • C81H105N3O18
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino-(polyethylene glycol)
  1. vPxk052g8q89C0P
Product

Paclitaxel-cholesterol conjugate-loaded DSPE-PEG:PC nanoparticles

Hydrodynamic diameter: 165 - 175 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • C81H105N3O18
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino-(polyethylene glycol)
  1. fZ4KJ7AzcSCrN8g
Product

Paclitaxel-cholesterol conjugate-loaded DSPE-PEG:PC nanoparticles

Hydrodynamic diameter: 125 - 175 nm

Medium: water

Support: none

References

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