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XL-184-loaded L-α-phosphatidylcholine/cholesterol/DSPE-PEG liposomes

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

water

Type Single Compound
Formula H2O
Role core
2

PC/cholesterol/DSPE-PEG mixture

Type Complex Compound
Formula
Role layer
3

cabozantinib

XL184
Type Single Compound
Formula C28H24FN3O5
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on media

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
male Balb/c- nu/nu mouse bearing renal cell carcinoma ACHN xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • L-α-phosphatidylcholine
  • cabozantinib
See all (4)
  1. fBYD4Yh4zO8sii1JM2dm6Mv3xGaEHT
Product

XL-184-loaded L-α-phosphatidylcholine/cholesterol/DSPE-PEG liposomes

Diameter: ~ 100 nm

Hydrodynamic diameter: 160 - 200 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • L-α-phosphatidylcholine
  • cabozantinib
See all (4)
  1. C2t6i5EHcR2vGuTiGJ0unDy2Rh3T5F
Product

XL-184-loaded L-α-phosphatidylcholine/cholesterol/DSPE-PEG liposomes

Hydrodynamic diameter: 137 - 175 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • L-α-phosphatidylcholine
  • cabozantinib
See all (4)
  1. bl6sNw41eXOCd4vp7S0E2mq9QZ4rjn
Product

XL-184-loaded L-α-phosphatidylcholine/cholesterol/DSPE-PEG liposomes

Hydrodynamic diameter: 142 - 204 nm

Medium: water

Support: none

References

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