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Cy5.5-labeled nanovesicles containing PLI/fluorescein-labeled miR complexes

Based on

1 Articles
2016 Most recent source

Composition

1

poly(L-lysine-graft-imidazole)

poly(L-lysine-g-imidazole) PLI
Type Biomolecule
Formula
Role core
2

fluorescein-conjugated microRNA

fluorescein-conjugated miR fluorescein-labeled miRNA FL-miR
Type Biomolecule
Formula
Role loaded material
3

[(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate

1-stearoyl-2- palmitoyl-sn-glycero-3-phosphocholine 1-palmitoyl-2-oleoyl-sn-glycero-3-phos-phocholine 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine palmitoyl-oleoyl-sn-glycero-phosphatidylcholine 1-palmitoyl-2-oleoylphosphatidylcholine palmitoyl oleoyl phosphatidylcholine palmitoyl-oleoyl-phosphatidylcholine palmitoyloleoyl-phosphatidylcholine palmitoyloleoylphosphatidyl choline Zwitterionic phosphatidylcholine L-α-phosphatidylcholine soy phosphatidylcholine phosphatidylcholine phospholipon 90 NG Phospholipon S100 PL S100 Egg-PC POPC POPS SPC PC EL
Type Single Compound
Formula C42H82NO8P
Role layer
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

amine-functionalized DSPE-PEG

Type Polymer
Formula
Role loaded material
6

N-hydroxysuccinimide ester modified Cy5.5

cyanine 5.5 N-hydroxysuccinimide ester cyanine5.5 N-hydroxysuccinimide ester hydroxysuccinimide ester of Cy5.5 Cy5.5 N-hydroxysuccinimide ester Cy5.5-N-hydroxysuccinimide ester cyanine 5.5 NHS ester Cyanine5.5 NHS ester Cy5.5 NHS ester Cy5.5-NHS ester Cy5.5-NHS-ester cyanine dye Cy5.5-NHS NHS-Cy5.5 Cy5.5
Type Single Compound
Formula C44H46N3O4Cl
Role layer

Properties

Applications

Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c-nude mouse with gastric cancer MKN-74 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • cholesterol
  • [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
  • amine-functionalized DSPE-PEG
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Product

Cy5.5-labeled nanovesicles containing PLI/fluorescein-labeled miR complexes

Size: not specified

Medium/Support: none

References

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