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follicle stimulating hormone receptor-targeted monoclonal antibody-functionalized 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated amino-PEGylated graphene oxide serum colloid

Based on

1 Articles
2016 Most recent source

Composition

1

graphene oxide

GO
Type Nano Material
Formula
Role core
2

PEG-NH2 moiety

Type Polymer
Formula
Role layer
3

(S)-2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid

2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid) 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid S-2-(4-Isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid 2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid p-SCN-Bn-NOTA SCN-Bn-NOTA
Type Single Compound
Formula C20H26N4O6S
Role layer
4

succinimidyl carboxymethyl PEG maleimide

SCM-PEG-Mal
Type Polymer
Formula
Role layer
5

thiolated monoclonal antibody against follicle stimulating hormone receptor

FSHR-mAb-SH
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
click beetle green luciferase-transfected MDA-MB-231 cells (cbgLuc-MDA-MB-231 cells)

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Preparation

Method 1

Type: Physical formation
Source:
Product

follicle stimulating hormone receptor-targeted monoclonal antibody-functionalized 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated amino-PEGylated graphene oxide serum colloid

Size: not specified

Medium: serum

Support: none

Method 2

Type: Physical formation
Source:
Product

follicle stimulating hormone receptor-targeted monoclonal antibody-functionalized 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated amino-PEGylated graphene oxide serum colloid

Hydrodynamic diameter: ~ 50 - ~ 1000 nm

Medium: aqueous buffer

Support: none

Method 3

Type: Chemical synthesis
Source:
  1. V0gSAbyjkqOrnYmBNPCQTrM9u6V9hbO4Ncn9NNbUEG3TbmSDENe039iKwb1mjR26QVe6ae5D
  2. KC6sd3u34e85UKW2CmSlRFNle
  3. qA85M5
  4. sNv3
Product

follicle stimulating hormone receptor-targeted monoclonal antibody-functionalized 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated amino-PEGylated graphene oxide serum colloid

Diameter: ~ 120 nm

Thickness: ~ 30 - ~ 50 nm

Medium/Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  1. ts48RRUO3bMYE4c3FI82pPit30bFrDxuOQVplbKe3Y3GE4eBiLKzB1q3UIDppOpsnkwPYWJH
  2. gpQrWCjjB1pGzLgwUDTIdMmWT
  3. MJe44I
  4. MevF
Product

follicle stimulating hormone receptor-targeted monoclonal antibody-functionalized 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated amino-PEGylated graphene oxide serum colloid

Size: not specified

Medium/Support: none

References

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