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RAP-loaded pH-responsive core-shell nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

acetalated β-cyclodextrin

acetalated β-CD Ac-bCD
Type Biomolecule
Formula
Role core
2

lecithin

Type Complex Compound
Formula
Role layer
3

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

DSPE-PEG
Type Polymer
Formula
Role loaded material
4

rapamycin

sirolimus RAPA RAP SR
Type Single Compound
Formula C51H79NO13
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release dependent on hydrogen peroxide presence

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
Sprague-Dawley rat vascular smooth muscle cells (VSMC)

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
  • lecithin
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  2. 2PVbyqY
Product

RAP-loaded pH-responsive core-shell nanoparticles

References

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