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DTX/IR820 co-loaded mPEG-PCL/PCL-g-PEI-g-PEG micelles

Based on

1 Articles
2016 Most recent source

Composition

1

methoxy poly(ethylene glycol)-poly(ε-caprolactone)

mPEG-PCL
Type Polymer
Formula
Role raw materials
2

PCL-g-PEI-g-PEG-Mal

Type Polymer
Formula
Role loaded material
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material
4

near-infrared dye IR-820

near-infrared dye IR820 New Indocyanine Green cyanine dye IR-820 cyanine dye IR820 IR 820 IR-820 IR820
Type Single Compound
Formula C46H50ClN2NaO6S2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on drugs

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Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Balb/c nude mouse with mouse mammary tumor 4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • near-infrared dye IR-820
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • methoxy poly(ethylene glycol)-poly(ε-caprolactone)
See all (4)
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Product

DTX/IR820 co-loaded mPEG-PCL/PCL-g-PEI-g-PEG micelles

Hydrodynamic diameter: ~ 45 nm

Medium/Support: none

References

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