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docetaxel-loaded D-α-tocopheryl succinate-conjugated hyaluronic acid nanoparticles

Based on

4 Articles
2017 Most recent source

Composition

1

acyl-chain saponin

ASAP
Type Single Compound
Formula C102H160O54
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
4T-1 murine breast cancer cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

docetaxel-loaded D-α-tocopheryl succinate-conjugated hyaluronic acid nanoparticles

Hydrodynamic diameter: 117.2 - 123.4 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • D-α-tocopheryl succinate-conjugated hyaluronic acid
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Product

docetaxel-loaded D-α-tocopheryl succinate-conjugated hyaluronic acid nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • DNA nanoparticles
Product

docetaxel-loaded D-α-tocopheryl succinate-conjugated hyaluronic acid nanoparticles

Hydrodynamic size: ~ 120.8 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • methoxy poly(ethylene glycol)-poly(lactide)-poly(β-amino ester)
  1. CEs2tvm9on6Y8QwIZZiroA0y
Product

docetaxel-loaded D-α-tocopheryl succinate-conjugated hyaluronic acid nanoparticles

Hydrodynamic diameter: 140.2 - 177.4 nm

Medium/Support: none

References

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