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chloroquine/docetaxel-loaded PEG5K-b-PLA8K nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactide)

PEG5K-b-PLA8K
Type Polymer
Formula
Role raw materials
2

chloroquine

CQ
Type Single Compound
Formula C18H26ClN3
Role loaded material
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast adenocarcinoma ALDH<sup>hi</sup> MDA-MB-231 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • chloroquine
  • poly(ethylene glycol)-block-poly(D,L-lactide)
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  2. ZM2PH
  3. Xkuzdn79BZcUh2a
  4. XFaj7SU
  5. EkD1YUlrISl6ZyBGmAcDg9w02KMl9u2km
Product

chloroquine/docetaxel-loaded PEG5K-b-PLA8K nanoparticles

Hydrodynamic diameter: 104.7 - 111.7 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • chloroquine
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. fd5NPSAyDrPnk5iapfNP3UVOMuf
  2. 9heMk
  3. RllLCZfNuR6uCBz
  4. Mn3ydnK
  5. 5IZLFEGDILnJlhO7ceDsgq0oFvni2rsr5
Product

chloroquine/docetaxel-loaded PEG5K-b-PLA8K nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • chloroquine
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. XRUVilfMr7qtzxOglWnCRv78Zf7
  2. CIjUF
  3. MzFETiPP0046kNb
  4. V0I8gMU
  5. 88m1T5mmM7NDsnL5P54jOcZ6yP43Y5zTj
Product

chloroquine/docetaxel-loaded PEG5K-b-PLA8K nanoparticles

Hydrodynamic diameter: 109.4 - 113.0 nm

Medium: water

Support: none

References

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