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Chlorin e6-doped mesoporous silica nanorods coated with bovine serum albumin via succine anhydride linker modified with polyethylene glycol/third generation polyamidoamine dendrimers conjugated with succinic acid-derivatized cis-platinum(IV)

Based on

1 Articles
2016 Most recent source

Composition

1

silicon dioxide

silicic oxide silica
Type Single Compound
Formula SiO2
Role raw materials
2

(17S,18S)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid

13-carboxy-17-(2-carboxyethyl)-15-carboxymethyl-17,18-trans-dihydro-3-vinyl-8-ethyl-2,7,12,18-tetramethylporphyrin Chlorin e6 chlorin e6 Chlorin Ce6
Type Single Compound
Formula C34H36N4O6
Role dopant
3

-C7H12NO6Si

Type Single Compound
Formula -C7H12NO6Si
Role layer
4

bovine serum albumin

Fraction V BSA
Type Biomolecule
Formula
Role layer
5

carboxyl-terminated poly(ethylene glycol)

carboxyl-terminated poly(ethylene oxide) carboxyl-terminated polyethylene glycol carboxyl-terminated polyethylene oxide carboxyl-terminated polyoxyethylene mPEG-COOH mPEO-COOH mPOE-COOH
Type Polymer
Formula
Role layer
6

PAMAM dendrimer G3

Type Polymer
Formula
Role loaded material
7

4-[(diaminodichlorohydroxyplatinio)oxy]-4-oxobutanoic acid

c,c,t-[Pt(NH3)2Cl2 (OOCCH2CH2COOH) (OH)] c,c,t-[Pt(NH3)2Cl2(OH)(O2CCH2CH2CO2H)] cisplatin prodrug Cis-Pt(NH3)2Cl2 DSP SCP
Type Single Compound
Formula Pt(NH3)2Cl2(OH)(O2CCH2CH2CO2H)
Role graft

Properties

Applications

Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
4T1 tumor-bearing female Balb/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
  1. sRyK
Product

Chlorin e6-doped mesoporous silica nanorods coated with bovine serum albumin via succine anhydride linker modified with polyethylene glycol/third generation polyamidoamine dendrimers conjugated with succinic acid-derivatized cis-platinum(IV)

Size: not specified

Medium/Support: none

References

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