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siRNA-loaded dendrimer/PEG-lipid/DSPC/cholesterol nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

dendrimer/PEG-lipid/DSPC/cholesterol mixture

Type Complex Compound
Formula
Role carriers
2

RNA

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
transgenic mouse bearing MYC-driven liver tumors

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • C93H173N5O20S5
See all (4)
  1. wF6vBFJ4KJDXTXQObT
Product

siRNA-loaded dendrimer/PEG-lipid/DSPC/cholesterol nanoparticles

Hydrodynamic diameter: ~ 45 - ~ 130 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
  • C78H144N4O16S4
See all (4)
  1. g7Hl9eYNDOXLSRpAY1
Product

siRNA-loaded dendrimer/PEG-lipid/DSPC/cholesterol nanoparticles

Hydrodynamic diameter: ~ 45 - ~ 150 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • C132H246N4O24S6
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
See all (4)
  1. eVxwyG1lI2gvJcsFJO
Product

siRNA-loaded dendrimer/PEG-lipid/DSPC/cholesterol nanoparticles

Hydrodynamic diameter: ~ 35 - ~ 120 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • C94H174N4O20S5
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
See all (4)
  1. hTHYza1D86tslz9lng
Product

siRNA-loaded dendrimer/PEG-lipid/DSPC/cholesterol nanoparticles

Hydrodynamic diameter: ~ 30 - ~ 120 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • C75H139N3O16S4
See all (4)
  1. 5NwzfhMRy1gKiM9DSs
Product

siRNA-loaded dendrimer/PEG-lipid/DSPC/cholesterol nanoparticles

Hydrodynamic diameter: ~ 45 - ~ 150 nm

Medium/Support: none

References

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