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Alexa fluor 488-modified doxorubicin-loaded trihydroxysilylpropyl methylphosphonate-modified mesoporous silica nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

trihydroxysilylpropyl methylphosphonate-modified mesoporous silica nanoparticles

THMP-modified MSN
Type Nano Material
Formula
Role carriers
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

(3-aminopropyl)trimethoxysilane moiety

(3-aminopropyl)trimethoxysilane moiety (3-aminopropyl)triethoxysilane moiety γ-aminopropyltriethoxy silane moiety 3-aminopropyltrimethoxysilane moiety γ-aminopropyltriethoxysilane moiety 3-aminopropyltriethoxysilane moiety (3-aminopropyl)trioxysilane moiety (3-aminopropyl)silanetrioxy group 3-aminopropylsilanetrioxy group 3-aminopropylsiloxy fragment 3-aminopropyl silane moiety 3-aminopropylsilane moiety γ-APTES moiety 3-APTS moiety APTES moiety APTMS moiety AMPS moiety APTS moiety APS moiety
Type Single Compound
Formula -C3H8NO3Si-
Role graft
4

Alexa fluor 488

Type Single Compound
Formula C25H27N2O9S
Role graft

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
fibrosarcoma HT1080 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. wTCCZkP
  2. sYCe
  3. V1m2
  4. rUqWrSMtbJQUSBZ
Product

Alexa fluor 488-modified doxorubicin-loaded trihydroxysilylpropyl methylphosphonate-modified mesoporous silica nanoparticles

Size: ~ 45 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. sPfIJIS
  2. kzC8
  3. ZejZ
  4. CR8TV3PfcbueAs1
Product

Alexa fluor 488-modified doxorubicin-loaded trihydroxysilylpropyl methylphosphonate-modified mesoporous silica nanoparticles

Size: ~ 150 nm

Medium/Support: none

References

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