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staurosporine/epirubicin co-loaded polyethylene glycol-b-poly(aspartate) micelles

Based on

1 Articles
2016 Most recent source

Composition

1

polyethylene glycol-block-poly(aspartate-hydrazide-epirubicin) copolymer

PEG-b-poly(aspartate-hydrazide-epirubicin) copolymer
Type Polymer
Formula
Role raw materials
2

(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro- 10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy- 1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7] benzodiazonin-1-one

staurosporine STS
Type Single Compound
Formula C28H26N4O3
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
epirubicin release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Epi-resistant MCF-7 (MCF-7 Epi-R) cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro- 10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy- 1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7] benzodiazonin-1-one
  • polyethylene glycol-block-poly(aspartate-hydrazide-epirubicin) copolymer
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Product

staurosporine/epirubicin co-loaded polyethylene glycol-b-poly(aspartate) micelles

Hydrodynamic diameter: ~ 50 nm

Medium: HEPES buffer

Support: none

References

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