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siRNA-loaded CD38-targeted lipid-based nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

lipid mixture

Type Complex Compound
Formula
Role core
2

mouse IgG1 anti-hCD38 monoclonal antibody THB-7

αCD38 mAb (clone THB-7) αCD38 mAb
Type Biomolecule
Formula
Role layer
3

small interfering Luc RNA

siLuc
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
genetic engineering

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female C.B-17/IcrHsd-Prkdcscid mouse bearing mantle cell lymphoma (Granta-519) cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

siRNA-loaded CD38-targeted lipid-based nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
  • cholesterol
  • DSPE-PEG-maleimide
See all (6)
  1. huH2qOUWjH18znRqeB
  2. dhJL3sAAvOlI0DL679d04qu
Product

siRNA-loaded CD38-targeted lipid-based nanoparticles

Hydrodynamic diameter: 108.1 - 123.9 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
  • cholesterol
  • DSPE-PEG-maleimide
See all (6)
  1. w8VZLBu2QaWLMRt8oR
  2. ipAD97j3TzC4Z9pzQmq7JoB
Product

siRNA-loaded CD38-targeted lipid-based nanoparticles

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Product

siRNA-loaded CD38-targeted lipid-based nanoparticles

Size: not specified

Medium: water

Support: none

References

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