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Pt-containing pH-instable clustered nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

PCL-CDM-PAMAM/Pt

Type Polymer
Formula
Role raw materials
2

poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG5000-b-PCL4700 PEG-b-PCL
Type Polymer
Formula
Role raw materials
3

hydroxyl-terminated PCL

polycaprolactone PCL
Type Polymer
Formula
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on ascorbic acid concentration

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c mouse with murine breast cancer 4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • hydroxyl-terminated PCL
  • poly(ethylene glycol)-b-poly(ε-caprolactone)
  • PCL-PAMAM/Pt
  1. q4qa6v85LvHEGKe7YTDXK7
Product

Pt-containing pH-instable clustered nanoparticles

Diameter: ~ 100 nm

Hydrodynamic diameter: 94.3 - 99.3 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • hydroxyl-terminated PCL
  • poly(ethylene glycol)-b-poly(ε-caprolactone)
  • PCL-CDM-PAMAM/Pt
  1. 4tMV5MmB7I4J2t57z18yaN
Product

Pt-containing pH-instable clustered nanoparticles

Diameter: ~ 100 nm

Hydrodynamic diameter: 100.8 - 107.4 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • hydroxyl-terminated PCL
  • poly(ethylene glycol)-b-poly(ε-caprolactone)
  • PCL-CDM-PAMAM/Pt
  1. QVhlD2Zs9jbdL93yIQWVfh
Product

Pt-containing pH-instable clustered nanoparticles

Hydrodynamic diameter: 86.6 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • hydroxyl-terminated PCL
  • poly(ethylene glycol)-b-poly(ε-caprolactone)
  • PCL-CDM-PAMAM/Pt
  1. rNqfpS6ZVeMRHjQGJv5XSf
Product

Pt-containing pH-instable clustered nanoparticles

Hydrodynamic diameter: 111.9 nm

Medium/Support: none

References

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