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doxorubicin-loaded HER2-specific affibody-modified nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

Saccharomyces cerevisiae vacuole

S. cerevisiae vacuole
Type Bioobject
Formula
Role core
2

human epidermal growth factor receptor 2-specific affibody

HER2-specific affibody
Type Biomolecule
Formula
Role layer
3

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
transmission electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c nude mouse bearing human epidermal growth factor receptor 2 (HER2)-overexpressing fibroblasts (NIH3T6.7)

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
Product

doxorubicin-loaded HER2-specific affibody-modified nanoparticles

Hydrodynamic diameter: ~ 50 - ~ 450 nm

Medium/Support: none

References

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