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(1,2-di-(9Z-octadecenoyl)-3-biguanide-propane lipid-protamine-DNA nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

water

Type Single Compound
Formula H2O
Role core
2

protamine

Type Biomolecule
Formula
Role carriers
3

TNF-related apoptosis-inducing ligand-expressing deoxyribonucleic acid

TRAIL-DNA
Type Biomolecule
Formula
Role loaded material
4

1,2-di(9Z-octadecenoyloxy)-3-trimethylammonium-propane chloride

N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride 1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane chloride 1,2-dioleoyl-3-trimethyl-ammonium-propane (chloride salt) (1,2-dioleoyloxypropyl)-N,N,N-trimethylammonium chloride 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) 1,2-dioleoyl-3-trimethylammonium-propane chloride salt 1,2-dioleoyl-3-trimethylammoniumpropane chloride salt 1,2-dioleoyloxy-3-trimethylammonium-propane chloride 1,2-dioleoyl-3-trimethyl-ammonium-propane chloride (2,3-dioleoyloxypropyl)trimethylammonium chloride 1,2-dioleoyl-3-(trimethylammonio)propane chloride 1,2-dioleoyl-3-trimethylammonium-propane chloride 2,3-dioleoyloxy-propyl-trimethylammonium chloride 1,2-di-O-octadecenyl-3-trimethylammonium-propane 1,2-dioleoyl-3-trimethylammoniumpropane chloride dioleoyltrimethyl-ammoniumpropane chloride DOTAP (chloride salt) DOTAP chloride DOTAP DOTMA
Type Single Compound
Formula C42H80ClNO4
Role layer
5

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
6

1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine

distearoyl phosphatidylethanolamine distearoylphosphatidylethanolamine distearoyl phoshatidylethanolamine distearoylphoshatidylethanolamine DSPE
Type Single Compound
Formula C41H82NO8P
Role loaded material
7

poly(ethylene glycol)

poly(ethylene oxide) polyethylene glycol polyethylene oxide polyoxyethylene PEG PEO POE
Type Polymer
Formula
Role layer
8

poly(ethylene glycol)/anisamide

PEG-anisamide
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female nude mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
Product

(1,2-di-(9Z-octadecenoyl)-3-biguanide-propane lipid-protamine-DNA nanoparticles

Size: 144.7 - 145.9 nm

Medium: phosphate buffer solution/fetal bovine serum

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-di-(9Z-octadecenoyl)-3-biguanide-propane
  1. nQ86gNpiet3xtyBaRsf
Product

(1,2-di-(9Z-octadecenoyl)-3-biguanide-propane lipid-protamine-DNA nanoparticles

Size: not specified

Medium/Support: none

References

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