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TNP-470&doxorubicin-loaded RGD-Ag2S quantum dots

Based on

1 Articles
2016 Most recent source

Composition

1

silver(I) sulfide

silver sulphide silver sulfide acanthite
Type Single Compound
Formula Ag2S
Role core
2

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-methoxypoly(ethylene glycol)

DSPE-mPEG
Type Polymer
Formula
Role layer
3

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol)-maleimide

DSPE-PEG-MAL
Type Polymer
Formula
Role layer
4

arginine-glycine-aspartic acid-D-phenylalanine-cysteine cyclic peptide

cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-cysteinyl) Arg-Gly-Asp-D-Phe-Cys cyclic pentapeptide cyclic Arg-Gly-Asp polypeptide cyclo(Arg-Gly-Asp-D-Phe-Cys) cyclic RGD polypeptide RGD peptide cyclic RGD cRGDfC cRGD RGD
Type Single Compound
Formula C24H34N8O7S
Role graft
5

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
6

(chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester

O-(chloroacetyl-carbamoyl)fumagillol TNP-470
Type Single Compound
Formula C19H28ClNO6
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human malignant glioma U87-MG cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • RGD-Ag2S quantum dots
  • adriblastin
  • (chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
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Product

TNP-470&doxorubicin-loaded RGD-Ag2S quantum dots

Diameter: ~ 3.8 nm

Hydrodynamic diameter: ~ 133 nm

Medium/Support: none

References

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