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mitoxantrone loaded gonadorelin modified PEGylated liposome

Based on

1 Articles
2010 Most recent source

Composition

1

1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione

1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino) ethylamino]-anthracene-9,10-dione mitoxantrone mitox MTO MTX Mit
Type Single Compound
Formula C22H28N4O6
Role core
2

cholesterol

Type Single Compound
Formula C27H46O
Role layer
3

hydrogenated soybean phosphatidylcholine

HSPC
Type Biomolecule
Formula
Role layer
4

gonadorelin modified N-(carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt

gonadorelin mPEG2000-DSPE
Type Polymer
Formula
Role layer
5

N-(carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt

mPEG2000-DSPE
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
mitoxantrone encapsulation dependent on in vitro drug release

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Applications

Area Application Source
medical devices

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
human (MCF-7) breast cancer cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • N-(carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt
  • hydrogenated soybean phosphatidylcholine
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Product

mitoxantrone loaded gonadorelin modified PEGylated liposome

References

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