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docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactide)

PEG-b-PLA
Type Polymer
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
Balb/c mouse xenografted with highly metastatic human prostate cancer PC3 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. mISMQXrrqnYG9dSicWiV3b
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. 7iIhi7nVg8iT6eHrFudeml
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. AaVlOYCUU46uLEHymwYhJ7
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. uEycuyZ8MCDf2VixEnNGCm
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. 8nBkiH1nWPVwQ3f28wm1n0
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

References

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