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docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Based on

17 Articles
2017 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactide)

PEG-b-PLA
Type Polymer
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Zeta potential

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
athymic nude mouse bearing A375SM-Luc melanoma lung metastases

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(ethylene glycol)-block-poly(D,L-lactic acid)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  1. Jb4W8yoRTx2TfgMmzPmDk
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • PEG-PCL nanoparticles
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  2. Dct3T9C
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Diameter: ~ 89.9 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Lipoid S100
  • Solutol HS15
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  4. o5sH
  5. OjaFM6ye
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Diameter: 20 - 25 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • polycaprolactone
  • poly(ethylene glycol)
  1. z8neOdETjEWtJpT8dJo5cR8GsBZkmSCEA
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Size: not specified

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(ethylene glycol)-block-poly(D,L-lactic acid)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  1. RZPWPxT5fycLOPgxzvXmi
Product

docetaxel-loaded poly(ethylene glycol)-block-poly(D,L-lactide) nanoparticles

Size: 17.99 - 18.11 nm

Medium/Support: none

References

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