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siRNA-loaded methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) blend

Meo-PEG-b-P(DPA-co-GMA-TEPA-C14)/iRGD-PEG-b-PDPA blend
Type Complex Compound
Formula
Role carriers
2

GL3 siRNA

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Source
Zeta potential

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Applications

Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
Renilla luciferase-expressing human cervical cancer cells (Luc-HeLa cells)

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. DKW
Product

siRNA-loaded methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. mfO
Product

siRNA-loaded methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. PwT
Product

siRNA-loaded methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) nanoparticles

Method 4

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. ugA
Product

siRNA-loaded methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) nanoparticles

Method 5

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. dD0
Product

siRNA-loaded methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) nanoparticles

References

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