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siRNA-loaded iRGD-NP

Based on

1 Articles
2016 Most recent source

Composition

1

methoxyl-polyethylene glycol-b-poly(methyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)/internalizing RGD-poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate) blend

Meo-PEG-b-P(MMA-co-GMA-TEPA-C14)/iRGD-PEG-b-PDPA blend
Type Complex Compound
Formula
Role carriers
2

GL3 siRNA

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Renilla luciferase-expressing human cervical cancer cells (Luc-HeLa cells)

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. z9K
Product

siRNA-loaded iRGD-NP

Hydrodynamic diameter: 82.1 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. DNy
Product

siRNA-loaded iRGD-NP

Hydrodynamic diameter: 68.3 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. NXc
Product

siRNA-loaded iRGD-NP

Hydrodynamic diameter: 86.3 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. 7Y6
Product

siRNA-loaded iRGD-NP

Hydrodynamic diameter: 70.7 nm

Medium: phosphate buffer solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • methoxyl-polyethylene glycol-b-poly(2-(diisopropyl amino)ethyl methacrylate-co-glycidyl methacrylate-tetraethylenepentamine-C14)
  1. VzT
Product

siRNA-loaded iRGD-NP

Hydrodynamic diameter: 76.5 nm

Medium: phosphate buffer solution

Support: none

References

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