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PEGylated palmitic acid-conjugated luc siRNA-loaded poly(ethylene glycol)-b-poly(2-(dimethylamino) ethyl methacrylate-co-butyl methacrylate) nanopolyplexes colloid

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-b-poly(2-(dimethylamino) ethyl methacrylate-co-butyl methacrylate)

PEG-b-p(DMAEMA-co-BMA)
Type Polymer
Formula
Role carriers
2

palmitic acid-conjugated small interfering RNA

palmitic acid-conjugated siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability dependent on sodium chloride concentration

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Applications

Area Application Nanomaterial Variant Source
genetic engineering

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
athymic nude female mouse bearing human epithelial breast cancer MDA-MB-231 cells constitutively expressing luciferase treated with luciferin

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • palmitic acid-conjugated small interfering RNA
  • poly(ethylene glycol)-b-poly(2-(dimethylamino) ethyl methacrylate-co-butyl methacrylate)
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  2. bij81o
Product

PEGylated palmitic acid-conjugated luc siRNA-loaded poly(ethylene glycol)-b-poly(2-(dimethylamino) ethyl methacrylate-co-butyl methacrylate) nanopolyplexes colloid

Size: not specified

Medium: phosphate buffer

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • palmitic acid-conjugated small interfering RNA
  • poly(ethylene glycol)-b-poly(2-(dimethylamino) ethyl methacrylate-co-butyl methacrylate)
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  2. UISHVa
Product

PEGylated palmitic acid-conjugated luc siRNA-loaded poly(ethylene glycol)-b-poly(2-(dimethylamino) ethyl methacrylate-co-butyl methacrylate) nanopolyplexes colloid

Hydrodynamic diameter: ~ 70 - ~ 140 nm

Medium: phosphate buffer

Support: none

References

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