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doxorubicin/sorafenib-loaded lipid-polymer hybrid nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000

MAL-PEG-DSPE
Type Polymer
Formula
Role layer
3

lecithin

Type Complex Compound
Formula
Role layer
4

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

sorafenib SFN SOR SF
Type Single Compound
Formula C21H16ClF3N4O3
Role loaded material
5

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability dependent on precursor ratio

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c mouse xenografted with human liver hepatocellular HepG2 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
Product

doxorubicin/sorafenib-loaded lipid-polymer hybrid nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • doxorubicin hydrogen chloride
  1. 69gyVQX550qTb
  2. 5Z4KpF2zkjBD6
  3. IjwGVCzz
Product

doxorubicin/sorafenib-loaded lipid-polymer hybrid nanoparticles

Hydrodynamic diameter: 105.1 - 128.5 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
Product

doxorubicin/sorafenib-loaded lipid-polymer hybrid nanoparticles

Hydrodynamic diameter: 105.1 - 128.5 nm

Medium: Dulbecco's modified Eagle medium

Support: none

References

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