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doxorubicin-encapsulated 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate-labeled recombinant human hyaluronidase PH20-modified poly(lactic-co-glycolic acid)-b-polyethylene glycol nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

poly(ethylene glycol)-b-poly(lactic-co-glycolic acid)

poly(lactic-co-glycolic acid)-b-polyethylene glycol PLGA20K-PEG5K PLGA-PEG
Type Complex Compound
Formula
Role core
2

thiolated recombinant human hyaluronidase PH20

thiolated rHuPH20
Type Biomolecule
Formula
Role layer
3

2-[(1E)-3-[(2Z)-3,3-dimethyl-1-octadecyl-2,3-dihydro-1H-indol-2-ylidene]prop-1-en-1-yl]-3,3-dimethyl-1-octadecyl-3H-indol-1-ium perchlorate

3H-indolium, 2-[3-(1,3-dihydro-3,3-dimethyl-1-octadecyl-2H-indol-2-ylidene)-1-propenyl]-3,3-dimethyl-1-octadecyl-, perchlorate 3H-indolium, 2-[3-(1,3-dihydro-3,3-dimethyl-1-octadecyl-2H-indol-2-ylidene)-1-propenyl]-3,3-dimethyl-1-octadecyl-perchlorate (2Z)-2-[(E)-3-(3,3-dimethyl-1-octadecylindol-1-ium-2-yl)prop-2-enylidene]-3,3-dimethyl-1-octadecylindole perchlorate 1,1';-dioctadecyl-3,3,3';,3';-tetramethylindocarbocyanine perchlorate 1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine perchlorate 1,1'- dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate 1,1'-dioctadecyl-3,3,3',3'-tetra-methylindocarbocyanine perchlorate 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate 1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbocyanine perchlorate 1,1-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate DiI-C18 lipophilic membrane dye carbocyanine-based fluorophore fluorescent whitening agent fluorescent dye D-282 DiIC18(3)) DiIC18(3) DiI-ClO4 DiI-C18 Dye Aye DiIC18 DiD DiI DIL Dil FWA
Type Single Compound
Formula C59H97ClN2O4
Role loaded material
4

methoxy-poly(ethylene-glycol)-thiol

PEG2k-thiol PEG2k-SH PEG-SH
Type Polymer
Formula
Role layer
5

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
6

methoxy-poly(ethylene glycol)-maleimide

PEG2k-maleimide PEG2k-MAL PEG-MAL
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
4T1 tumor-bearing female BALB/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • doxorubicin hydrogen chloride
  1. WMI9f8JRn7IIA
  2. 6UvdEdFZzs1iCYzXexDFviKA0C2aVPke
  3. 9JwJ6Cl8QL4Y9Yqw
Product

doxorubicin-encapsulated 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate-labeled recombinant human hyaluronidase PH20-modified poly(lactic-co-glycolic acid)-b-polyethylene glycol nanoparticles

Hydrodynamic size: ~ 90 nm

Medium/Support: none

References

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