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drugs-loaded targeted lipid-polymer hybrid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

5-Fu solution

Type Complex Compound
Formula
Role core
2

methoxy poly(ethylene glycol)-poly(lactic acid)

mPEG-PLA
Type Polymer
Formula
Role layer
3

(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

irinotecan Camptosa CPT
Type Single Compound
Formula C33H38N4O6
Role loaded material
4

Oxa solution

Type Complex Compound
Formula
Role layer
5

phospholipids mixture

Type Complex Compound
Formula
Role layer
6

arginine-glycine-aspartic acid-D-phenylalanine-cysteine cyclic peptide

cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-cysteinyl) Arg-Gly-Asp-D-Phe-Cys cyclic pentapeptide cyclic Arg-Gly-Asp polypeptide cyclo(Arg-Gly-Asp-D-Phe-Cys) cyclic RGD polypeptide RGD peptide cyclic RGD cRGDfC cRGD RGD
Type Single Compound
Formula C24H34N8O7S
Role layer
7

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
healthy female BALB/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 5-Fu solution
  • methoxy poly(ethylene glycol)-poly(lactic acid)
  • (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
  1. VvAtCt2xXdi1yL6ocDeu4WJoZviSifxF2
  2. HLbya
Product

drugs-loaded targeted lipid-polymer hybrid nanoparticles

Hydrodynamic diameter: ~ 160 nm

Thickness: ~ 15 nm

Medium/Support: none

References

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