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gefitinib-loaded pTSA-complexed 2-hydroxypropyl-β-cyclodextrin-polyethylenimine nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

2-hydroxypropyl-β-cyclodextrin-polyethylenimine

HCP
Type Polymer
Formula
Role carriers
2

Gefitinib

gefitinib Iressa ZD1839
Type Single Compound
Formula C22H24ClFN4O3
Role loaded material
3

plasmid DNA

pDNA pGL3
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
genetic engineering

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Characterization

Method Nanomaterial Variant Source
scanning electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
female C57BL/6 mouse bearing Lewis lung cancer cells xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • Gefitinib
  • 2-hydroxypropyl-β-cyclodextrin-polyethylenimine
  1. JQC0hphUERyFXlZf80SO
  2. cV12I
Product

gefitinib-loaded pTSA-complexed 2-hydroxypropyl-β-cyclodextrin-polyethylenimine nanoparticles

Size: 100 - 300 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 2-hydroxypropyl-β-cyclodextrin-polyethylenimine
  • Gefitinib
  1. e6EvW2GVNVKAUiqgdLxq
  2. vb8oq
Product

gefitinib-loaded pTSA-complexed 2-hydroxypropyl-β-cyclodextrin-polyethylenimine nanoparticles

Size: not specified

Medium/Support: none

References

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