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docetaxel/curcumin-loaded 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)/L-α-phosphatidyl-DL-glycerol/L-α-phosphatidyl-DL-glycerol-coated poly(lactic-co-glycolic acid) nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material
3

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

1,7-bis(4-hydroxy-3-methoxy phenyl)-1,6-heptadiene-3,5-diene 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione keto form curcumin diferuloylmethane curcumin CCM CUM CUR Cum Cur CM CU Cm
Type Single Compound
Formula C21H20O6
Role loaded material
4

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)/L-α-phosphatidyl-DL-glycerol

DSPE-PEG/L-α-phosphatidyl-DL-glycerol
Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
drug release

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
scanning electron microscopy

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Biological effects

Biological system Test details Source
glioblastoma multiforme cell line (U-87 MG) bearing female athymic nude mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]
  • L-α-phosphatidyl-DL-glycerol
  1. yMKbCFg
  2. 3HN3F
Product

docetaxel/curcumin-loaded 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)/L-α-phosphatidyl-DL-glycerol/L-α-phosphatidyl-DL-glycerol-coated poly(lactic-co-glycolic acid) nanoparticles

References

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