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human Erythropoietin mRNA loaded ionizable lipid OF-02/cholesterol/DOPE/C14-PEG 2000 lipid nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

3,6-bis(4-{bis[(9Z,12Z)-2-hydroxyoctadeca-9,12-dien-1-yl]amino}butyl)piperazine-2,5-dione/cholesterol/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine mixture

3,6-bis(4-{bis[(9Z,12Z)-2-hydroxyoctadeca-9,12-dien-1-yl]amino}butyl)piperazine-2,5-dione/cholesterol/DOPE mixture
Type Complex Compound
Formula
Role core
2

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-(polyethyleneglycol)-2000] (ammonium salt)

C14-PEG 2000
Type Polymer
Formula
Role layer
3

human Erythropoietin messenger ribonucleic acid

human Erythropoietin mRNA EPO mRNA
Type Biomolecule
Formula
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
genetic engineering

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Characterization

Method Nanomaterial Variant Source
cryo-electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
female C57BL/6 mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-(polyethyleneglycol)-2000] (ammonium salt)
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
See all (4)
  1. RFFIo3Fy31g8fUeE4
Product

human Erythropoietin mRNA loaded ionizable lipid OF-02/cholesterol/DOPE/C14-PEG 2000 lipid nanoparticles

Diameter: ~ 100 nm

Hydrodynamic diameter: 122 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-(polyethyleneglycol)-2000] (ammonium salt)
  • (2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid
See all (4)
  1. 2e7jZdif7IbmSg1bQ
Product

human Erythropoietin mRNA loaded ionizable lipid OF-02/cholesterol/DOPE/C14-PEG 2000 lipid nanoparticles

Diameter: ~ 100 nm

Hydrodynamic diameter: 122 nm

Medium/Support: none

References

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