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trastuzumab-conjugated PEG/PEI-modified mesoporous silica nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

mesoporous silica nanoparticles

MSNP
Type Nano Material
Formula
Role core
2

DSP-cross-linked poly(iminoethylene)

DSP-cross-linked polyethyleneimine DSP-cross-linked PEI
Type Polymer
Formula
Role layer
3

mal-PEG-5 kDa

Type Polymer
Formula
Role layer
4

thiolated trastuzumab

Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
buffering capacity

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Applications

Area Application Nanomaterial Variant Source
genetic engineering

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer BT474 cell line

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  1. q1WJIMk
  2. ifxzZWDoxp2BrCCI
  3. Uc8
Product

trastuzumab-conjugated PEG/PEI-modified mesoporous silica nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  1. JdNb0hC
  2. SeZdJcotwCvj9Prk
  3. MTl
Product

trastuzumab-conjugated PEG/PEI-modified mesoporous silica nanoparticles

Hydrodynamic diameter: 114.6 - 119.4 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  1. AVEorX3
  2. PWxQQ7HFaLt7KsB1
  3. Bjh
Product

trastuzumab-conjugated PEG/PEI-modified mesoporous silica nanoparticles

Hydrodynamic diameter: 116.5 - 117.5 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  1. QdOf71s
  2. XhfEbtb3BV9Rgfod
  3. Lc3
Product

trastuzumab-conjugated PEG/PEI-modified mesoporous silica nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  1. 3TV85wH
  2. xtfR2jSg4gELXSHU
  3. hZ7
Product

trastuzumab-conjugated PEG/PEI-modified mesoporous silica nanoparticles

Hydrodynamic diameter: 128.9 - 137.1 nm

Medium: phosphate buffer solution

Support: none

References

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