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siRNA-loaded poly(amido amine) dendrimer-terminated disulfide-linked branched polyethylene glycol hollow nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

Vacuous

Type
Formula
Role core
2

poly(amido amine) dendrimer-terminated disulfide-linked branched polyethylene glycol

PAMAM G2/bPEG hybrid polymer PAMAM G2-terminated bPEG
Type Polymer
Formula
Role layer
3

B-cell lymphoma 2 small interfering RNA

Bcl-2 siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
diagnostics

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human liver cancer SMMC-7721 cell line-treated female athymic BALB/c mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • pGL3-Luc
  • sodium chloride/water
Product

siRNA-loaded poly(amido amine) dendrimer-terminated disulfide-linked branched polyethylene glycol hollow nanoparticles

Hydrodynamic diameter: ~ 220 - 250 nm

Medium: sodium chloride/water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • FITC-labeled siRNA
  • sodium chloride/water
Product

siRNA-loaded poly(amido amine) dendrimer-terminated disulfide-linked branched polyethylene glycol hollow nanoparticles

Hydrodynamic diameter: ~ 130 - 190 nm

Medium: sodium chloride/water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • B-cell lymphoma 2 small interfering RNA
  • poly(amido amine) dendrimer-terminated disulfide-linked branched polyethylene glycol
  1. aVj3z5ppyS1Q1fc6ilHLRma7q3yiVq8Ll
Product

siRNA-loaded poly(amido amine) dendrimer-terminated disulfide-linked branched polyethylene glycol hollow nanoparticles

Size: not specified

Medium/Support: none

References

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