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siRNA-loaded poly(ethylene glycol)-b-poly(ε-caprolactone):poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate):poly(ε-caprolactone) micellar nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(ethylene glycol)-b-poly(ε-caprolactone):poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate):poly(ε-caprolactone)

mPEG-b-PCL:PCL-b-PPEEA:PCL
Type Complex Compound
Formula
Role carriers
2

FAM-labeled siRNA

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
SiRNA release

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Applications

Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/nu-nu nude mouse bearing GFP-expressing human breast cancer (MDA-MB-231)

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Preparation

Method 1

Type: Physical formation
Source:
Product

siRNA-loaded poly(ethylene glycol)-b-poly(ε-caprolactone):poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate):poly(ε-caprolactone) micellar nanoparticles

Size: 180 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

siRNA-loaded poly(ethylene glycol)-b-poly(ε-caprolactone):poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate):poly(ε-caprolactone) micellar nanoparticles

Size: 40 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Product

siRNA-loaded poly(ethylene glycol)-b-poly(ε-caprolactone):poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate):poly(ε-caprolactone) micellar nanoparticles

Size: 90 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Product

siRNA-loaded poly(ethylene glycol)-b-poly(ε-caprolactone):poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate):poly(ε-caprolactone) micellar nanoparticles

Size: 130 nm

Medium/Support: none

References

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