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siTTR-loaded cKK-E12 lipopeptide nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

anti-transthyretin siRNA

siTTR
Type Biomolecule
Formula
Role loaded material
3

C60H120N4O6

Type Single Compound
Formula C60H120N4O6
Role layer
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate

non-deuterated 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycerol-3-phosphatidylcholine 1,2-distearoyl-sn-glycero-3-phosphatidylcholine 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine L-α 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphorylcholine hydrogenated soy sn-glycero-3-phosphocholine 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-Distearoyl-sn-glycero-3-phosphocholine hydrogenated soybean phosphatidylcholine hydrogenated soy L-α-phosphatidylcholine distearoyl-sn-glycero-3-phosphocholine hydrogenated soya phosphatidylcholine hydrogenated soy phosphatidylcholine Hydrogenated soy phosphatidylcholine hydrogenated L-α-phosphatidylcholine distearyl-L-α-phosphatidylcholine distearoyl phosphatidylcholine distearyl phosphatidyl choline distearoylphosphatidylcholine L-α-phosphatidylcholine egg PC hDSPC HSPC DSPC DSCP
Type Single Compound
Formula C44H88NO8P
Role loaded material
6

(R)-3-[(ω-methoxy-PEG2000-carbamoyl)]-1,2-di-O-tetradecyl-sn-glyceride

mPEG2000-DMG mPEG2000-DMG
Type Polymer
Formula
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
Cynomolgus monkey

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • anti-transthyretin siRNA
  • C60H120N4O6
  • cholesterol
See all (5)
Product

siTTR-loaded cKK-E12 lipopeptide nanoparticles

Size: not specified

Medium/Support: none

References

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