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hyaluronic acid-shielded doxorubicin/R8-loaded thioketal/3-aminopropyltriethoxysilane-functionalized zinc oxide nanococktail

Based on

1 Articles
2016 Most recent source

Composition

1

zinc oxide nanoparticles

ZnO nanoparticles
Type Nano Material
Formula
Role core
2

3-aminopropyltriethoxysilane

APTES
Type Single Compound
Formula C9H23NO3Si
Role layer
3

3-({2-[(2-carboxyethyl)sulfanyl]propan-2-yl}sulfanyl)propanoic acid

thioketal
Type Single Compound
Formula C9H16O4S2
Role graft
4

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role graft
5

R8

Type Biomolecule
Formula
Role graft
6

hyaluronic acid

HA
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on hyaluronidase presence

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c nude mice

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Preparation

Method 1

Type: Physical formation
Source:
Product

hyaluronic acid-shielded doxorubicin/R8-loaded thioketal/3-aminopropyltriethoxysilane-functionalized zinc oxide nanococktail

Diameter: 37.5 - 38.3 nm

Medium: PBS/FBS mixture

Support: none

Method 2

Type: Chemical synthesis
Source:
  1. mXaoUirtAtqcw7Os
Product

hyaluronic acid-shielded doxorubicin/R8-loaded thioketal/3-aminopropyltriethoxysilane-functionalized zinc oxide nanococktail

Diameter: 37.5 - 38.3 nm

Medium/Support: none

References

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