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Janus doxorubicin-conjugated 7-hydroxycoumarin-3-carboxylate incorporated mesoporous silica/6-mercaptopurine-conjugated gold nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

7-hydroxycoumarin-3-carboxylate incorporated mesoporous silica

CMR incorporated MS CMR-MS
Type Nano Material
Formula
Role core
2

(3-isocyanatopropyl)triethoxysilane moiety

3-(triethoxysilyl)propyl isocyanate moiety 3-isocyanatopropyltriethoxysilane moiety i-CNPTES moiety ICPTES moiety TESPIC moiety
Type Single Compound
Formula -C4H6NO4Si-
Role loaded material
3

adipic acid dihydrazide

adipic acid hydrazide dihydrazide adipate adipic dihydrazide AADH ADH
Type Single Compound
Formula C6H14N4O2
Role loaded material
4

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
5

(3-mercaptopropyl)trimethoxysilane moiety

3-mercaptopropyltrimethoxysilane moiety (3-mercaptopropyl)silanetrioxy group 3-mercaptopropyltrimethoxysilane 3-MPTMOxS moiety SIM6476.0 moiety MPTMS moiety MPTS moiety MPS moiety
Type Single Compound
Formula -C3H7O3SSi-
Role binder
6

gold nanoparticles

Au nanoparticles gold NP Au NP AuNP GNP
Type Nano Material
Formula
Role core
7

6-mercaptopurine

mercaptopurine 6-MP 6MP
Type Single Compound
Formula C5H4N4S
Role partial layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
doxorubicin release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HeLa cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 3-(triethoxysilyl)propyl isocyanate
  • adipic acid dihydrazide
  1. GCPHeQrzdXlZUY
  2. qob60TrD
Product

Janus doxorubicin-conjugated 7-hydroxycoumarin-3-carboxylate incorporated mesoporous silica/6-mercaptopurine-conjugated gold nanoparticles

Diameter: ~ 130 nm

Medium/Support: none

References

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