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mRNA-loaded lipid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

C12-200/DOPC

Type Complex Compound
Formula
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

C14-PEG 2000
Type Polymer
Formula
Role layer
5

human erythropoietin mRNA

EPO mRNA
Type Biomolecule
Formula
Role loaded material

Properties

Applications

Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
female C57BL/6 mice

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. tWs548jLktt9y5TQMx
Product

mRNA-loaded lipid nanoparticles

Size: 135 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. rOqgAvM5QrHbC3nw2w
Product

mRNA-loaded lipid nanoparticles

Size: 173 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  • 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
See all (4)
  1. 1Scea7B7HB7oBfFCDo
Product

mRNA-loaded lipid nanoparticles

Size: 352 nm

Medium/Support: none

References

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