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doxorubicin-loaded-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol-LyP1 peptide/hydrogenated hsoy sn-glycero-3-phosphocholine/cholesterol liposomes

Based on

1 Articles
2014 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

distearoyl phosphatidylethanolamine-polyethylene glycol-LyP1 peptide:hydrogenated soy sn-glycero-3-phosphocholine

distearoyl phosphatidylethanolamine-polyethylene glycol-ARAL peptide:hydrogenated soy sn-glycero-3-phosphocholine DSPE-PEG-LyP1:HSPC DSPE-PEG-ARAL:HSPC
Type Complex Compound
Formula
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
bilateral MDA-MB-435 tumor bearing nude mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • distearoyl phosphatidylethanolamine-polyethylene glycol-ARAL peptide
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
See all (4)
Product

doxorubicin-loaded-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol-LyP1 peptide/hydrogenated hsoy sn-glycero-3-phosphocholine/cholesterol liposomes

Hydrodynamic diameter: ~ 90 - ~ 500 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • distearoyl phosphatidylethanolamine-polyethylene glycol-LyP1 peptide
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
See all (4)
Product

doxorubicin-loaded-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol-LyP1 peptide/hydrogenated hsoy sn-glycero-3-phosphocholine/cholesterol liposomes

Hydrodynamic diameter: ~ 90 - ~ 500 nm

Medium/Support: none

References

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