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siRNA-loaded FITC-doped poly(ethylene glycol)monomethyl ether monomethacrylate/triethylene glycol dimethacrylate-grafted poly(2-(diethylamino)ethyl methacrylate) hydrogel-coated silica nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

silicon dioxide

silicic oxide silica
Type Single Compound
Formula SiO2
Role core
2

poly(ethylene glycol)monomethyl ether monomethacrylate/triethylene glycol dimethacrylate-grafted poly(2-(diethylamino)ethyl methacrylate)

PEGMA/TEGDMA-grafted PDEAEM
Type Polymer
Formula
Role layer
3

water

Type Single Compound
Formula H2O
Role loaded material
4

3',6'-dihydroxy-5-isothiocyanato-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one

fluorescein-5-isothiocyanate fluorescein isothiocyanate FITC
Type Single Compound
Formula C21H11NO5S
Role dopant
5

siRNA

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer cell line (MDA-MB-231)

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Preparation

Method 1

Type: Physical formation
Source:
  1. y29FQ3abguN7cHUhviPqotJ9AI3Z9zGbIETvbITQDPH7pjhQK8NiKiqC
  2. 7azzUboH
  3. rvUD11TWTNLFrZ
Product

siRNA-loaded FITC-doped poly(ethylene glycol)monomethyl ether monomethacrylate/triethylene glycol dimethacrylate-grafted poly(2-(diethylamino)ethyl methacrylate) hydrogel-coated silica nanoparticles

Thickness: 10 nm

Medium/Support: none

References

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