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irinotecan-loaded liposomes

Based on

1 Articles
2016 Most recent source

Composition

1

water

Type Single Compound
Formula H2O
Role core
2

DSPC/cholesterol/DSPE-PEG2000

lipid biofilm
Type Complex Compound
Formula
Role layer
3

triethylammonium sucrose octasulfate

TEA8SOS
Type Complex Compound
Formula
Role loaded material
4

(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

irinotecan Camptosa CPT
Type Single Compound
Formula C33H38N4O6
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
cryo-electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
immunocompetent B6/129 mouse with KPC-derived orthotopic tumor

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
Product

irinotecan-loaded liposomes

Hydrodynamic diameter: 98.6 nm

Size: ~ 75 nm

Thickness: ~ 7 nm

Medium: DMEM/FBS

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
Product

irinotecan-loaded liposomes

Hydrodynamic diameter: 102 nm

Size: ~ 75 nm

Thickness: ~ 7 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
See all (4)
  1. DagQptPweznRDkzU2B
  2. DDX9U
Product

irinotecan-loaded liposomes

Size: ~ 75 nm

Thickness: ~ 7 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
Product

irinotecan-loaded liposomes

Hydrodynamic diameter: 104.7 nm

Size: ~ 75 nm

Thickness: ~ 7 nm

Medium: phosphate buffer solution

Support: none

References

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