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matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Based on

1 Articles
2016 Most recent source

Composition

1

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol network polymer

CS22-MMP-Lys/8-PEG-Gln network polymer
Type Polymer
Formula
Role raw materials
2

water

Type Single Compound
Formula H2O
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
chondroitinase mediated degradation

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Applications

Area Application Nanomaterial Variant Source
implants

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
bone morphogenetic protein-2 (BMP-2)

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. 2xxlWDwlhRH
  2. dzNg8FZOga46i4dgrjHLoZjSDbu86KbsYFKDt
  3. et4diSswdy7fuNSnK0rKPxal8F9y
  4. POQRG
  5. wwpXx4mjVclbOZtJss80L
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 21.2 - 22.0 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. UV1VliIMpMZ
  2. QEGKPPUwVWXxvDttUFtXPjTkDohsjeI6ljQqC
  3. dyVsWkHNwxIoYVcXRjE3ZnFjp7lM
  4. g5aNs
  5. gf5TBlNkSwN4WTYsxkEJR
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 42.3 - 43.1 nm

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. vRgcmxu7hb0
  2. xuFF3JmKwwYjPoiUNg2ZorhG7SZU2VB1pAubO
  3. 0L8zYNtbnUpV2OMgqklThpFBUwms
  4. rLmAL
  5. lsGe1bxiy6NCSY0FgnELT
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 20.1 - 21.9 nm

Medium/Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. Bqx5fjtC9hv
  2. RA7A3MtE1zL7tmyKuu2FRXEFrIgLmjU5kWViz
  3. Wp24qeE3t4w5qE1DkyZafrLveOHz
  4. Uw1zA
  5. MkcAQgeIIlCyiphJaIouU
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 21 - 23.4 nm

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. j0dKqd3yYZT
  2. u3UeFpSscsIW1XDxr4aovMzDHvSB85XwuPfIb
  3. jURcy20Y2BYaAMlMmO1tgvybI0iP
  4. jqHPo
  5. HK1p9Q97uhbnxNgOJuCSY
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Mesh size: 39.1 - 39.7 nm

Medium/Support: none

References

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