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matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Based on

1 Articles
2016 Most recent source

Composition

1

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol network polymer

CS22-MMP-Lys/8-PEG-Gln network polymer
Type Polymer
Formula
Role raw materials
2

water

Type Single Compound
Formula H2O
Role raw materials

Properties

General physical and chemical properties

Property Value Source
chondroitinase mediated degradation

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Applications

Area Application Source
implants

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Characterization

Biological effects

Biological system Test details Source
bone morphogenetic protein-2 (BMP-2)

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. zr5VyNUvysh
  2. te45zauEc0BHSXWKJJp4ZiNHaJzJT2hu1rUX3
  3. dFk4gw3ncmMXgYmjZof0RexOcotB
  4. QaFg2
  5. AhHI690MSfYbPITt5Bimc
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. hLxfiHlSeHs
  2. u6ik7tpQCvXtWyQU3T2RUIRGpFOKYV2XLryq8
  3. 8EpB2mWzHzdz3GrEKkf5sq6QkEs5
  4. gNUgJ
  5. 3UZjb82W80Av9JyQQ5E8b
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. w0gGylMnq3Q
  2. mLaavHb54oLqQN0VArct6wq2G1fZVpd9XbNH0
  3. W6tR4CIw9QsvzoJWEcDEaHfEckT3
  4. 9teE8
  5. xBpYetoPMED4Kml2PKRCL
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. GANSyEFV5Ek
  2. uYGYDZEmYht1VATYgruMnq31roF6GYFWSJIuH
  3. OMhYm2WHE7DtXjiAzXNXcJXKlfWq
  4. DTk7k
  5. wBIycwDSxRP7hl2hb2GMS
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • Lys-tagged RGD
  • glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol
  • lysine peptide/maleimide-functionalized chondroitin sulfate
  1. MgJoIMLSvJQ
  2. imOmBMQmq6bYfgbLm02xJyMspjzTMmZAn4e5S
  3. uj2K17dBhip4hGRJctC8LNeSqosn
  4. FK9k5
  5. lCVoyM5ZiBBy9ns0oMcUY
Product

matrix metalloproteinase sensitive lysine peptide/maleimide-functionalized chondroitin sulfate/glutamine peptide-functionalized vinyl sulfone-linked eight-arm polyethylene glycol-based hydrogel

References

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