Loading ...

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

liver X receptor agonist GW3965 LXR agonist GW3965 GW3965
Type Single Compound
Formula C33H32Cl2F3NO3
Role core
2

poly(D,L-lactide-co-glycolide)-GW3965

PLGA-GW3965
Type Polymer
Formula
Role layer
3

poly(D,L-lactide)-b-poly(ethylene glycol)

PLA9K-PEG2K PLA-PEG
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

More information/entries available to subscribers only.

Or, view sample content

Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

More information available to subscribers only.

Or, view sample content

Biological effects

Biological system Test details Nanomaterial Variant Source
mouse peritoneal macrophages

More information available to subscribers only.

Or, view sample content

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. 8yNyfgIC0zz8GVs6KyBqmtz
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 115.3 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. tNubtuArGe6MbnMw7pISu5n
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 151.1 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. 8it9sEvLfTmboKRksT6QoK5
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 187.8 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. aNFZxfYifbzhMCe45Qkg7ZY
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 248.5 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(D,L-lactide)-b-poly(ethylene glycol)
  • poly(D,L-lactide-co-glycolide)-GW3965
  • 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  1. aDN9UThqigbyLWhDA1iXcMn
Product

GW3965-loaded poly(D,L-lactide)-b-poly(ethylene glycol)/poly(D,L-lactide-co-glycolide)-GW3965 nanoparticles

Hydrodynamic diameter: 111.3 nm

Medium: water

Support: none

References

Full content is available to subscribers only

To view content please choose from the following:

We use cookies to improve your experience with our site. More information

Sign up for a free trial