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T7-PEG-modified lipid/rPAA-Chol/siRNA hybrid nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

rPAA-Chol/siRNA nanoplexes

Type Nano Material
Formula
Role core
2

(9Z)-9-octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine 1,2-dioleoyl-sn-glycero-3-phosphorylethanolamine 1,2-dioctanoyl-sn-glycero-3-phosphoethanolamine 1,2-dioleoyl-sn-glycero- 3-phosphoethanolamine 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-dioleoylphosphatidylethanolamine dioleoyl phosphatidylethanolamine dioleoylphosphatidylethanolamine Lipoid PE 18:1/18:1 DOPE
Type Single Compound
Formula C41H78NO8P
Role layer
3

N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium

(N-[1-(2, 3-dioleoyloxy)propyl]-N,N,N-trimethylammoniumsalt) 1,2-di(9Z-octadecenoyloxy)-3-trimethylammonium-propane N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium 1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane 1,2-dioleoyloxy-3-trimethylammonium-propane 1,2-dioleoyl-3-(trimethylammonium)propane 1,2-dioleoyl-3-trimethyl-ammonium-propane 1,2-dioleoyl-3-trimethylammonium propane 1,2-dioleoyl-3-trimethylammonium-propane 1,2-dioleoyl-3-trimethylammonium-propan 1,2-dioleoyl-3-trimethylammoniumpropane DOTAP
Type Single Compound
Formula C42H80NO4
Role loaded material
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

DSPE-PEG2000-T7

Type Polymer
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Source
stability against heparin displacement

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Applications

Characterization

Method Source
cryo-electron microscopy

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Biological effects

Biological system Test details Source
human breast cancer MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  1. UG7xYlqt
  2. 0DYO
Product

T7-PEG-modified lipid/rPAA-Chol/siRNA hybrid nanoparticles

References

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