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simvastatin-loaded 1-myristoyl-2-hydroxy-sn-glycero-phosphocholine/1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine/human apolipoprotein A-1 nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

simvastatin

SIM SMV
Type Single Compound
Formula C25H38O5
Role core
2

1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine

1-myristoyl-2-hydroxy-sn-glycero-phosphocholine myristoyl-hydroxyl-phosphatidylcholine l-a-lysophosphatidylcholine MHPC
Type Single Compound
Formula C22H46NO7P
Role layer
3

(2R)-2,3-bis(tetradecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate

1,2-dimyristoyl-sn-glycero-3-phosphocholine dimyristoyl-2-hydroxy-sn-glycero-3-phosphocholine 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine 1,2-dinonadecanoyl-sn-glycero-3-phosphocholine 1,2-dimyristoyl-sn-glycero-3- phosphocholine 1,2-dimyristoyl-sn-glycero-3-phosphocholine 2-dimyristoyl-sn-glycero-3-phosphocholine dimyristoyl-sn-glycero-3-phosphocholine L-α-dimyristoylphosphatidylcholine dimyristoyl phosphatidylcholine dimyristoylphosphatidylcholine di-14:0PC DMPC DMPE
Type Single Compound
Formula C36H72NO8P
Role layer
4

human apolipoprotein A-1

human ApoA1 lipoprotein
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
atherosclerosis-developed apolipoprotein E-knockout (apoE-KO) mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • simvastatin
  • (2R)-2,3-bis(tetradecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
  • 1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine
  1. 1OjbOeGCHinD71vYWYt9380WydNI
Product

simvastatin-loaded 1-myristoyl-2-hydroxy-sn-glycero-phosphocholine/1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine/human apolipoprotein A-1 nanoparticles

Diameter: 19.9 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

simvastatin-loaded 1-myristoyl-2-hydroxy-sn-glycero-phosphocholine/1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine/human apolipoprotein A-1 nanoparticles

Hydrodynamic diameter: 27 nm

Medium: phosphate buffer solution

Support: none

References

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