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DTX-loaded PLGA-b-HA nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

1,4-butylenediamine

butane-1,4-diamine 1,4-butanediamine 1,4-diaminobutane diaminobutane putrescine BDA D88 BD
Type Single Compound
Formula C4H12N2
Role layer
3

hyaluronic acid

HA
Type Biomolecule
Formula
Role layer
4

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release dependent on pH

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
X-ray diffraction

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Biological effects

Biological system Test details Source
human breast adenocarcinoma MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)-block-hyaluronic acid
  1. Sp5YVIRr9JNuOUtM4Dy3FpA5zwB0UogUMD
  2. ApSrdqJm
Product

DTX-loaded PLGA-b-HA nanoparticles

References

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