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CPT-loaded mAP/PEG/PEI/pTRAIL/PEI-coated PLGA nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

poly(iminoethylene)

polyethyleneimine polyaziridine PEI
Type Polymer
Formula
Role layer
3

pEGFP-TRAIL

pTRAIL
Type Biomolecule
Formula
Role layer
4

poly(iminoethylene)

polyethyleneimine polyaziridine PEI
Type Polymer
Formula
Role layer
5

maleimide-terminated PEG

Type Polymer
Formula
Role layer
6

antennapedia

mAP
Type Biomolecule
Formula
Role layer
7

(S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione

1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione (S)-(+)-camptothecin camptothecin CPT CMT CP
Type Single Compound
Formula C20H16N2O4
Role loaded material
8

iRGD

Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
drug release dependent on CPT initial loading

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Applications

Area Application Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Source
human breast adenocarcinoma MDA-MB-231 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
  • poly(lactic-co-glycolic acid)
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Product

CPT-loaded mAP/PEG/PEI/pTRAIL/PEI-coated PLGA nanoparticles

References

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