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7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactic acid)

PEG2K-PLA2K
Type Polymer
Formula
Role carriers
2

tert-butyl 4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-{[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy}-3-oxopropyl]-1H-imidazole-1-carboxylate

Type Single Compound
Formula C38H43N5O10
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HCT-116 colorectal xenograft mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(ethylene glycol)-block-poly(D,L-lactic acid)
  • tert-butyl 4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-{[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy}-3-oxopropyl]-1H-imidazole-1-carboxylate
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Product

7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Size: 10 - 22 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Hydrodynamic diameter: 17 - 23 nm

Medium: water

Support: none

References

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