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7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

poly(ethylene glycol)-block-poly(D,L-lactic acid)

PEG8K-PLA16K
Type Polymer
Formula
Role carriers
2

(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl (9Z)-octadec-9-eneoate

Type Single Compound
Formula C40H52N2O6
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HCT-116 colorectal xenograft mouse

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Preparation

Method 1

Type: Physical formation
Source:
Product

7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Hydrodynamic diameter: 36 - 46 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(ethylene glycol)-block-poly(D,L-lactic acid)
  • (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl (9Z)-octadec-9-eneoate
  1. yR8IQLTMpyf6
  2. zwAcm
Product

7-ethyl-10-hydroxycamptothecin-derived prodrug-encapsulated polymer nanoparticles

Size: 21 - 31 nm

Medium/Support: none

References

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